UC Riverside scored six runs in the fourth inning to take a lead it would not relinquish.
Santa Clara collected three homers and three triples en route to beating LMU 10-2.
LMU had its seven-game hit streak snapped at BYU on Friday night.
LMU beat #21 UC Irvine on Tuesday to extend its winning streak to six games.
LMU surrendered eight runs over the first two innings and could not climb out of the early hole.
Sixth-year head coach Jason Gill previews the 2014 LMU baseball season.
2014 LMU Baseball Alumni Game